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Save your library (the .ENL file and associated .DATA folder) into a single compressed .enlx file to back it up.
To compress your library:
Important to note: You can save your Compressed Library (.enlx file) to cloud syncing folders, but you'll need to move it to your local drive i.e. Local Disc (C:) before you open and edit it.
Related information: EndNote: Moving, backing up, or transferring libraries to another computer.
Synchronise your EndNote 21 Library contents (references, groups and file attachments) with a free EndNote online account.
Access your references from another computer directly from a web browser using EndNote online.
Set up EndNote sync:
Important to note: Do not move/rename your EndNote library files after they are synchronized as this breaks the link to the Sync target library. Only sync and share one primary library. Attempting to sync multiple libraries will merge references of both EndNote libraries.